Liquid Chromatographic, Spectrophotometric and Potentiometric pK_a Determination of Ranitidine and Famotidine

Title:Liquid Chromatographic, Spectrophotometric and Potentiometric pK_a Determination of Ranitidine and Famotidine

Volume: 9 Issue: 4

Author(s): Y. Dogan Daldal, Cansel Cakır, Hulya Yılmaz, Ebru Cubuk Demiralay, Sibel A. Ozkan and Guleren Alsancak

Affiliation:

Keywords: Acetonitrile-water mixtures, aqueous pK_a value, dissociation constant, H₂ receptor antagonists, molecular structure, RPLC.

Abstract: The dissociation constant (pK_a) is one of the most significant properties of a substance chemical moiety which has to be estimated with accuracy. Liquid chromatographic, spectrophotometric and potentiometric methods are often employed for determination of pK_a values of compounds. This study describes the practice of these three methods to the determination of dissociation constant values of famotidine and ranitidine in acetonitrile-water binary mixtures. From these constants, aqueous dissociation constants of investigated substances were calculated by different approaches.

Moreover, estimation of aqueous pK_a values ( ^w_wpK_a ) can also be predicted by computational

method (Marvin Sketch) on the basis of molecular structure. Results obtained from ^w_wpK_a values are compared with Marvin Sketch program and literature values.

Cite this article as:

Dogan Daldal Y., Cakır Cansel, Yılmaz Hulya, Cubuk Demiralay Ebru, A. Ozkan Sibel and Alsancak Guleren, Liquid Chromatographic, Spectrophotometric and Potentiometric pK_a Determination of Ranitidine and Famotidine, Current Drug Therapy 2014; 9 (4) . https://dx.doi.org/10.2174/157488550904150525164412