Structure Diversity, Synthesis, and Biological Activity of Cyathane Diterpenoids in Higher Fungi

Title:Structure Diversity, Synthesis, and Biological Activity of Cyathane Diterpenoids in Higher Fungi

Volume: 22 Issue: 19

Author(s): Hao-Yu Tang, Xia Yin, Cheng-Chen Zhang, Qian Jia and Jin-Ming Gao

Affiliation:

Keywords: Basidiomycete, cyathane diterpenes, enantioselective synthesis, mushroom, natural products, NGF synthesis inducers, structure-activity relationships.

Abstract: Cyathane diterpenoids, occurring exclusively in higher basidiomycete (mushrooms), represent a structurally diverse class of natural products based on a characteristic 5-6-7 tricyclic carbon scaffold, including 105 members reported to date. These compounds show a diverse range of biological activities, such as antimicrobial, anti-MRSA, agonistic toward the kappa-opioid receptor, antiinflammatory, anti-proliferative and nerve growth factor (NGF)-like properties. The present review focuses on the structure diversity, structure elucidation and biological studies of these compounds, including mechanisms of actions and structure-activity relationships (SARs). In addition, new progress in chemical synthesis of cyathane diterpenoids is discussed.

Cite this article as:

Tang Hao-Yu, Yin Xia, Zhang Cheng-Chen, Jia Qian and Gao Jin-Ming, Structure Diversity, Synthesis, and Biological Activity of Cyathane Diterpenoids in Higher Fungi, Current Medicinal Chemistry 2015; 22 (19) . https://dx.doi.org/10.2174/0929867322666150521091333