α¯ Aminoisobutyric Acid Leads a Fluorescent syn-bimane LASER Probe Across the Blood-brain Barrier

Title:α¯ Aminoisobutyric Acid Leads a Fluorescent syn-bimane LASER Probe Across the Blood-brain Barrier

Volume: 12 Issue: 1

Author(s): Inbal Lapidot, Danny Baranes, Albert Pinhasov, Gary Gellerman, Amnon Albeck, Flavio Grynszpan and Shimon E. Shatzmiller

Affiliation:

Keywords: Blood-brain barrier, fluorescence microscopy, fluorescent probe, LASER dye, syn-bimane.

Abstract: Penetration of the blood brain barrier (BBB) by appropriate fluorescent probes remains a challenge in optical imaging and diagnostics. We designed, synthesized and observed the in vivo BBB penetration of a LASER syn-bimane probe. Results demonstrate that the Aib transporter unit in our probe may lead a fluorescent bimanyl moiety across the BBB.

Cite this article as:

Lapidot Inbal, Baranes Danny, Pinhasov Albert, Gellerman Gary, Albeck Amnon, Grynszpan Flavio and E. Shatzmiller Shimon, α¯ Aminoisobutyric Acid Leads a Fluorescent syn-bimane LASER Probe Across the Blood-brain Barrier, Medicinal Chemistry 2016; 12 (1) . https://dx.doi.org/10.2174/1573406411666150518105010