Inflammation Fuels Tumor Progress and Metastasis

Jingyi      Liu; Pengnian   Charles   Lin; Binhua   P.   Zhou

doi:10.2174/1381612821666150514105741

Abstract

Inflammation is a beneficial response that can remove pathogens, repair injured tissue and restore homeostasis to damaged tissues and organs. However, increasing evidence indicate that chronic inflammation plays a pivotal role in tumor development, as well as progression, metastasis, and resistance to chemotherapy. We will review the current knowledge regarding the contribution of inflammation to epithelial mesenchymal transition. We will also provide some perspectives on the relationship between ER-stress signals and metabolism, and the role of these processes in the development of inflammation.

Keywords: Epithelial-mesenchymal transition, inflammation, metastasis.

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Current Pharmaceutical Design

Title:Inflammation Fuels Tumor Progress and Metastasis

Volume: 21 Issue: 21

Author(s): Jingyi Liu, Pengnian Charles Lin and Binhua P. Zhou

Affiliation:

Keywords: Epithelial-mesenchymal transition, inflammation, metastasis.

Abstract: Inflammation is a beneficial response that can remove pathogens, repair injured tissue and restore homeostasis to damaged tissues and organs. However, increasing evidence indicate that chronic inflammation plays a pivotal role in tumor development, as well as progression, metastasis, and resistance to chemotherapy. We will review the current knowledge regarding the contribution of inflammation to epithelial mesenchymal transition. We will also provide some perspectives on the relationship between ER-stress signals and metabolism, and the role of these processes in the development of inflammation.

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Liu Jingyi, Lin Charles Pengnian and Zhou P. Binhua, Inflammation Fuels Tumor Progress and Metastasis, Current Pharmaceutical Design 2015; 21 (21) . https://dx.doi.org/10.2174/1381612821666150514105741

DOI https://dx.doi.org/10.2174/1381612821666150514105741	Print ISSN 1381-6128
Publisher Name Bentham Science Publisher	Online ISSN 1873-4286