Synthesis of Daumone Derivatives and their Antiangiogenic Activities on Chorioallantoic Membrane

Title:Synthesis of Daumone Derivatives and their Antiangiogenic Activities on Chorioallantoic Membrane

Volume: 11 Issue: 8

Author(s): Jeremy Ricci, Dongguk Min, Miyeon Oh, Hyenchong Lim, Won-Yoon Chung, Kwang-Kyun Park and Mankil Jung

Affiliation:

Keywords: Daumone, glycolipid, antiangiogenic activity, synthesis.

Abstract: Daumone, a dauer-inducing pheromone and a series of lipid derivatives were synthesized from daumone to investigate structure-activity trends. Lipid derivatives demonstrated potent in vivo antiangiogenic activity on the chorioallantoic membrane, which exceeded that of fumagillin and thalidomide as reference agents. Among the 11 synthetic compounds tested, new derivatives 3, 11 and 13 showed the most potent antiangiogenic activity, which was twice that of fumagillin and thalidomide, replacing these as the most potent known antiangiogenic agents.

Cite this article as:

Ricci Jeremy, Min Dongguk, Oh Miyeon, Lim Hyenchong, Chung Won-Yoon, Park Kwang-Kyun and Jung Mankil, Synthesis of Daumone Derivatives and their Antiangiogenic Activities on Chorioallantoic Membrane , Medicinal Chemistry 2015; 11 (8) . https://dx.doi.org/10.2174/1573406411666150514100630