Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging

Title:Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging

Volume: 8

Author(s): Gaetano Santulli and Andrew R. Marks

Affiliation:

Keywords: Aging, arrhythmias, cognitive dysfunction, diabetes, excitation-contraction coupling, heart failure, IP3 receptors, metabolism, mitochondria, neurodegenerative disorders, RyR, skeletal muscle.

Abstract: Calcium (Ca²⁺) release from intracellular stores controls numerous cellular processes, including cardiac and skeletal muscle contraction, synaptic transmission and metabolism. The ryanodine receptors (RyRs: RyR1, RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1, IP3R2, IP3R3) are the major Ca²⁺ release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR). RyRs and IP3Rs comprise macromolecular signaling complexes that include modulatory proteins which regulate channel activity in response to extracellular signals resulting in intracellular Ca²⁺ release. Here we focus on the roles of CRCs in heart, skeletal muscle, brain, metabolism, and aging.

Cite this article as:

Santulli Gaetano and R. Marks Andrew, Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging, Current Molecular Pharmacology 2015; 8 (2) . https://dx.doi.org/10.2174/1874467208666150507105105