Calcium Channel Signaling Complexes with Receptors and Channels

Title:Calcium Channel Signaling Complexes with Receptors and Channels

Volume: 8

Author(s): Gerald W. Zamponi

Affiliation:

Keywords: Calcium channels, G proteins, receptors, potassium channels, calcium-activated potassium channels, cell signaling.

Abstract: Voltage-gated calcium channels are not only mediators of cell signalling events, but also are recipients of signalling inputs from G protein coupled receptors (GPCRs) and their associated second messenger pathways. The coupling of GPCRs to calcium channels is optimized through the formation of receptor-channel complexes. In addition, this provides a mechanism for receptorchannel co-trafficking to and from the plasma membrane. On the other hand, voltage-gated calcium channel activity affects other types of ion channels such as voltage-and calcium-activated potassium channels. Coupling efficiency between these two families of channels is also enhanced through the formation of channel-channel complexes. This review provides a concise overview of the current state of knowledge on the physical interactions between voltage-gated calcium channels and members of the GPCR family, and with other types of ion channels.

Cite this article as:

Zamponi W. Gerald, Calcium Channel Signaling Complexes with Receptors and Channels, Current Molecular Pharmacology 2015; 8 (1) . https://dx.doi.org/10.2174/1874467208666150507093116