Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas aeruginosa PAO1 in vitro

Title:Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas aeruginosa PAO1 in vitro

Volume: 16 Issue: 8

Author(s): Boris Pejin, Ana Ciric, Jasmina D. Markovic, Jasmina Glamoclija, Milos Nikolic, Bojana Stanimirovic and Marina Sokovic

Affiliation:

Keywords: Anti-biofilm activity, Anti-quorum sensing effects, Flavonoids, Pseudomonas aeruginosa PAO1.

Abstract: This work was focused on in vitro evaluation of anti-biofilm and anti-quorum sensing effects of four selected flavonoid compounds /(+)-catechin, caffeic acid, quercetin and morin/ using the strain Pseudomonas aeruginosa PAO1. At a concentration of 0.5 MIC quercetin was the only compound found to potently reduce both P. aeruginosa biofilm formation (95%) and its twitching motility. The chemical scaffold of quercetin, a common dietary polyphenol, may actually inspire development of novel and more effective medicinal agents targeting P. aeruginosa, the bacterium well known for its resistance.

Cite this article as:

Pejin Boris, Ciric Ana, D. Markovic Jasmina, Glamoclija Jasmina, Nikolic Milos, Stanimirovic Bojana and Sokovic Marina, Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas aeruginosa PAO1 in vitro, Current Pharmaceutical Biotechnology 2015; 16 (8) . https://dx.doi.org/10.2174/1389201016666150505121951