Protein Tyrosine Phosphatases and their Inhibitors

Purushottam   M.   Dewang; Nai-Mu      Hsu; Shao-Zheng      Peng; Wen-Ren      Li

doi:10.2174/0929867053363504

Abstract

Protein tyrosine phosphatase (PTP) is the family of enzymes that are key players in cellular signal transduction system and perturbation in their functioning is implicated in many disease-states. Diverse chemical compounds are being synthesized and evaluated as PTP inhibitors. This review presents a brief account of various enzymes of the PTP family and their inhibitors. Peculiar features of these enzymes and their roles in various diseases are summarized along with important inhibitors developed in recent years.

Keywords: cellular signaling, diseases, ptps, sar, inhibitors, therapeutics/drugs

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Current Medicinal Chemistry

Title: Protein Tyrosine Phosphatases and their Inhibitors

Volume: 12 Issue: 1

Author(s): Purushottam M. Dewang, Nai-Mu Hsu, Shao-Zheng Peng and Wen-Ren Li

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Keywords: cellular signaling, diseases, ptps, sar, inhibitors, therapeutics/drugs

Abstract: Protein tyrosine phosphatase (PTP) is the family of enzymes that are key players in cellular signal transduction system and perturbation in their functioning is implicated in many disease-states. Diverse chemical compounds are being synthesized and evaluated as PTP inhibitors. This review presents a brief account of various enzymes of the PTP family and their inhibitors. Peculiar features of these enzymes and their roles in various diseases are summarized along with important inhibitors developed in recent years.

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Dewang M. Purushottam, Hsu Nai-Mu, Peng Shao-Zheng and Li Wen-Ren, Protein Tyrosine Phosphatases and their Inhibitors, Current Medicinal Chemistry 2005; 12 (1) . https://dx.doi.org/10.2174/0929867053363504