Abstract
During recent 30 years, successful efforts have been made to develop useful electrophilic fluorinating and fluoroalkylating reagents in spite of the difficulty of generating fluorine cation (F+) and fluoroalkyl cation (F-C+). With this advancement, a wide variety of reactions between these reagents and organometallics have been reported as one of the most straightforward ways to introduce fluorinated functional groups. This review focuses on the progress of the fluorination and fluoroalkylation of organolithium, magnesium, and zinc reagents, including trifluoromethylation, difluoromethylation, bromodifluoromethylation, fluoro(di)halomethylation, perfluoroalkylation, carbonylfluoromethylation, and miscellaneous fluoroalkylations.
Keywords: Organofluorine compound, fluorination, fluoroalkylation, electrophilic reagent, organometallic reagent.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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