冠状动脉疾病中的新型炎症生物标记物：潜在的治疗方法

Title:Novel Inflammatory Biomarkers in Coronary Artery Disease: Potential Therapeutic Approaches

Volume: 22 Issue: 22

Author(s): Konstantinos V. Voudris, Jake Chanin, Dmitriy N. Feldman and Konstantinos Charitakis

Affiliation:

关键词: 生物标记物，冠状动脉疾病，炎症，急性冠脉综合征。

摘要: Coronary artery disease constitutes the leading cause of mortality and morbidity in the modern world. Inflammation has been implicated to play a key role in the initiation and promotion of atherosclerosis, and the induction of plaque instability, possibly leading to acute coronary syndrome (ACS). This review aims to assess the clinical utility of well established (CRP) and novel inflammatory biomarkers (Homocyesteine, SAA, sCD40L, sLOX-1, IMA, MPO, PAPP-A and MMPs) in the diagnosis and outcome prediction of patients with ACS. The PubMed database was searched for reports using the terms “biomarkers”, “acute coronary syndrome”, “infarction”, “markers” and only original articles written in English were included. The diversity of novel biomarkers for coronary artery disease provides an insight of the varied pathophysiology of this disease. A better understanding of their properties and assimilation in daily clinical use is essential for optimal management and patient care in the future.

Cite this article as:

Konstantinos V. Voudris, Jake Chanin, Dmitriy N. Feldman and Konstantinos Charitakis , Novel Inflammatory Biomarkers in Coronary Artery Disease: Potential Therapeutic Approaches, Current Medicinal Chemistry 2015; 22 (22) . https://dx.doi.org/10.2174/0929867322666150420124427