Circulating Biomarkers Determining Inflammation in Atherosclerosis Progression

Title:Circulating Biomarkers Determining Inflammation in Atherosclerosis Progression

Volume: 22 Issue: 22

Author(s): Gerasimos Siasos, Vicky Tsigkou, Evangelos Oikonomou, Marina Zaromitidou, Sotiris Tsalamandris, Konstantinos Mourouzis, Manolis Vavuranakis, Maria Anastasiou, Konstantinos Vlasis, Maria Limperi, Vasiliki Gennimata, John N. Boletis, Athanasios G. Papavassiliou and Dimitris Tousoulis

Affiliation:

Keywords: Atherosclerosis, biological markers, cardiovascular diseases, cardiovascular risk, cytokines, inflammation, interleukins.

Abstract: Atherosclerosis is the main underlying pathology of cardiovascular disease and is precipitated by various hereditary and non-hereditary risk factors. Inflammation is considered an important step in the progression of atherosclerosis and involves numerous cells, mediators and cellular procedures. Therefore, a biomarker able to determine the vascular inflammatory status is imperative as the combination of inflammatory biomarkers with the classic risk factors might provide further information about atherosclerosis progression and cardiovascular risk. The identification of novel inflammatory molecules and the improvement in analytical methods allows the potential implementation of these tests in every day clinical practice. In the current article, we focus on the role of established and novel biomarkers in atherosclerosis progression and in the determination of cardiovascular risk. We also present recent data concerning the risk stratification of patients according to their inflammatory status and the possible anti-inflammatory treatment strategies.

Cite this article as:

Siasos Gerasimos, Tsigkou Vicky, Oikonomou Evangelos, Zaromitidou Marina, Tsalamandris Sotiris, Mourouzis Konstantinos, Vavuranakis Manolis, Anastasiou Maria, Vlasis Konstantinos, Limperi Maria, Gennimata Vasiliki, Boletis N. John, Papavassiliou G. Athanasios and Tousoulis Dimitris, Circulating Biomarkers Determining Inflammation in Atherosclerosis Progression, Current Medicinal Chemistry 2015; 22 (22) . https://dx.doi.org/10.2174/0929867322666150415125828