Molecular Modeling Based Synthesis and Evaluation of In vitro Anticancer Activity of Indolyl Chalcones

Title:Molecular Modeling Based Synthesis and Evaluation of In vitro Anticancer Activity of Indolyl Chalcones

Volume: 15 Issue: 11

Author(s): Rashmi Gaur, Dharmendra K. Yadav, Shiv Kumar, Mahendra P. Darokar, Feroz Khan and Rajendra Singh Bhakuni

Affiliation:

Keywords: 1, 3-Diaryl-2-propen-1-ones, Anticancer agents, Indolyl chalcones.

Abstract: A series of twenty one chalcone derivatives having indole moiety were synthesized and were evaluated against four human cancer cell lines. Indolyl chalcones 1a, 1b, 1d, 1f-1j, 2c, 2e, 2i showed good anticancer activity. Chalcones 1b and 1d were the most active and selective anticancer agents with IC₅₀ values <1μg/ml and 1.51μg/ml, against WRL-68 cell line, respectively. Molecular mechanism was explored through in silico docking & ADMET studies.

Cite this article as:

Gaur Rashmi, Yadav K. Dharmendra, Kumar Shiv, Darokar P. Mahendra, Khan Feroz and Bhakuni Singh Rajendra, Molecular Modeling Based Synthesis and Evaluation of In vitro Anticancer Activity of Indolyl Chalcones, Current Topics in Medicinal Chemistry 2015; 15 (11) . https://dx.doi.org/10.2174/1568026615666150317222059