Straightforward Three-Component Palladium-Catalysed Synthesis of Pyridazin-3(2H)-one Libraries

Alberto      Coelho; Eddy      Sotelo

doi:10.2174/138620706775213868

Abstract

A simple and straightforward three-component methodology for the solution phase high-throughput synthesis of 2,5-disubstituted pyridazin-3(2H)-one libraries has been developed. The diversity at position 5 of the heterocycle is determined by the use of Suzuki, Sonogashira, Heck or Stille coupling.

Keywords: Multicomponent reactions, pyridazinones, palladium, combinatorial chemistry

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Combinatorial Chemistry & High Throughput Screening

Title: Straightforward Three-Component Palladium-Catalysed Synthesis of Pyridazin-3(2H)-one Libraries

Volume: 9 Issue: 1

Author(s): Alberto Coelho and Eddy Sotelo

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Keywords: Multicomponent reactions, pyridazinones, palladium, combinatorial chemistry

Abstract: A simple and straightforward three-component methodology for the solution phase high-throughput synthesis of 2,5-disubstituted pyridazin-3(2H)-one libraries has been developed. The diversity at position 5 of the heterocycle is determined by the use of Suzuki, Sonogashira, Heck or Stille coupling.

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Coelho Alberto and Sotelo Eddy, Straightforward Three-Component Palladium-Catalysed Synthesis of Pyridazin-3(2H)-one Libraries, Combinatorial Chemistry & High Throughput Screening 2006; 9 (1) . https://dx.doi.org/10.2174/138620706775213868