Pattern Recognition by CD6: A Scavenger-Like Lymphocyte Receptor

Title:Pattern Recognition by CD6: A Scavenger-Like Lymphocyte Receptor

Volume: 17 Issue: 6

Author(s): Adelaida Sarukhan, Mario Martinez-Florensa, Cristina Escoda-Ferran, Esther Carrasco, Esther Carreras and Francisco Lozano

Affiliation:

Keywords: Bacteria, CD5, CD6, lipopolysaccharide, lipoteichoic acid, pathogen-associated molecular patterns (PAMPs), pattern- recognition receptor (PRR), peptidoglycan, scavenger receptor cysteine-rich (SRCR).

Abstract: CD6, one of the first antigens to be identified on T cells, is a membrane glycoprotein that physically associates with the antigen receptor complex. Because of this, its main function seems to involve the modulation of TCR-mediated signaling pathways. However, growing evidence indicates that this ancient and conserved scavenger-like receptor may also play a role as pattern recognition receptor (PRR), similar to other members of the scavenger receptor cysteine rich superfamily (SRCR-SF). Here, we discuss the functional interactions of CD6 with microbe- and damage-associated signals and the potential use of soluble forms of CD6 in the therapeutic treatment of bacterial infections, in particular multi-drug resistant bacterial strains. Importantly, microbe recognition by CD6 may also have functional consequences on T cell activation and differentiation, which remain to be explored.

Cite this article as:

Sarukhan Adelaida, Martinez-Florensa Mario, Escoda-Ferran Cristina, Carrasco Esther, Carreras Esther and Lozano Francisco, Pattern Recognition by CD6: A Scavenger-Like Lymphocyte Receptor, Current Drug Targets 2016; 17 (6) . https://dx.doi.org/10.2174/1389450116666150316224308