Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents

Title:Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents

Volume: 14 Issue: 1

Author(s): Prasanna A. Datar and Saleel A. Limaye

Affiliation:

Keywords: Analgesic activity, Mannich bases, N1-substituted benzimidazoles.

Abstract: Mannich bases were selected for 2D QSAR study to derive meaningful relationship between the structural features and analgesic activity. Using the knowledge of important features a novel series was designed to obtain improved analgesic activity. A series of novel Mannich bases 1-(N-substituted amino)methyl]-2-substituted benzimidazole derivatives were synthesized and were screened for analgesic activity. Some of these compounds showed promising analgesic activity when compared with the standard drug diclofenac sodium.

Cite this article as:

A. Datar Prasanna and A. Limaye Saleel, Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2015; 14 (1) . https://dx.doi.org/10.2174/1871523014666150312164625