Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors from the Natural Origin: A Recent Perspective

Title:Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors from the Natural Origin: A Recent Perspective

Volume: 15 Issue: 8

Author(s): Harun M. Patel, Rajesh Rane, Neeta Thapliyal, Mahesh Palkar, Mahamadhanif Shaikh and Rajshekhar Karpoormath

Affiliation:

Keywords: Epidermal growth factor receptor, Natural origin, SAR.

Abstract: Overexpression of epidermal growth factor receptor (EGFR) is seen in a number of human tumors like prostate, colon, breast and ovarian. Their expression is correlated with vascularity and often difficult to diagnose. Though a number of active inhibitors and anticancer drugs against EGFR-tyrosine kinase are known, increase in resistance together with many side effects designate the need for new and improved treatments. Natural products and their analoges have significant contribution in the cancer drug discovery and development process. Therefore in the current review we mainly discuss design, synthesis and structural activity relationship of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors from the natural origin.

Cite this article as:

Patel M. Harun, Rane Rajesh, Thapliyal Neeta, Palkar Mahesh, Shaikh Mahamadhanif and Karpoormath Rajshekhar, Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors from the Natural Origin: A Recent Perspective, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (8) . https://dx.doi.org/10.2174/1871520615666150312100259