Potential and Limitations of Intervertebral Disc Endogenous Repair

Title:Potential and Limitations of Intervertebral Disc Endogenous Repair

Volume: 10 Issue: 4

Author(s): Zhen Li, Marianna Peroglio, Mauro Alini and Sibylle Grad

Affiliation:

Keywords: Annulus fibrosus, endogenous repair, intervertebral disc, nucleus pulposus, progenitor cells, stem cell niche

Abstract: Intervertebral disc (IVD) disorders, especially degenerative disc disease, reduce the quality of life, and are short of effective therapy. A new direction for treatment of chronic tissue and organ diseases is to promote regeneration by harnessing endogenous repair mechanisms. In this review, we discuss the potential of endogenous repair in the IVD, the recent findings on endogenous IVD progenitor cells, and stem cell niches involved in IVD endogenous repair. We also highlight the factors which may restrict IVD self-healing. Ultimately, advanced therapeutic attempts to boost endogenous repair in the IVD are discussed, including bioactive factor delivery, gene therapy, activation of endogenous IVD progenitor cells and chemokine mediated stem cell homing

Cite this article as:

Li Zhen, Peroglio Marianna, Alini Mauro and Grad Sibylle, Potential and Limitations of Intervertebral Disc Endogenous Repair, Current Stem Cell Research & Therapy 2015; 10 (4) . https://dx.doi.org/10.2174/1574888X10666150305105114