摘要
天冬氨酸蛋白酶、半胱氨酸蛋白酶和氨肽酶是与人血红蛋白降解及红细胞浸润与破裂过程息息相关的恶性疟原虫蛋白酶。由于抗疟药物的耐药性和寄生虫的自然选择的,我们必须寻求新的作用靶点以使药物达到治疗疟疾的目的。本文总结了蛋白酶和血红蛋白降解抑制剂的研究进展。此外,本文还概括了in silico 生物学预测抗疟药物的靶点、平衡选择和药物-蛋白质相互作用等内容。
关键词: 血红蛋白降解,天冬氨酸蛋白酶,半胱氨酸蛋白酶,药物靶点,疟疾,多态性。
图形摘要
Current Drug Targets
Title:Hemoglobin Degrading Proteases of Plasmodium falciparum as Antimalarial Drug Targets
Volume: 16 Issue: 10
Author(s): Tabish Qidwai
Affiliation:
关键词: 血红蛋白降解,天冬氨酸蛋白酶,半胱氨酸蛋白酶,药物靶点,疟疾,多态性。
摘要: Plasmepsins, falcipains and aminopeptidases are Plasmodium falciparum proteases involved in human host hemoglobin degradation and other processes like erythrocyte invasion and rupture. Antimalarial drug resistance and natural selection in parasite are important reasons that create the urgent need of novel targets and lead compounds to overcome the burden of malaria. This report explored progress of the study covering proteases and their inhibitors specific to hemoglobin degradation. Additionally, in silico predicted antimalarial targets, balancing selection and drug-protein interaction are included.
Export Options
About this article
Cite this article as:
Tabish Qidwai , Hemoglobin Degrading Proteases of Plasmodium falciparum as Antimalarial Drug Targets, Current Drug Targets 2015; 16 (10) . https://dx.doi.org/10.2174/1389450116666150304104123
DOI https://dx.doi.org/10.2174/1389450116666150304104123 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Antiviral Activity of Trichilia catigua Bark Extracts for Herpesvirus and Poliovirus
Current Pharmaceutical Biotechnology Combinatorial Application of Multiple High-throughput Biotechnologies for the Study of Autoimmune Diseases
Current Pharmaceutical Analysis Immunological Mechanism and Clinical Application of PAMP Adjuvants
Recent Patents on Anti-Cancer Drug Discovery Probiotics: An Emerging Therapy
Current Pharmaceutical Design Apoptotic Signaling Pathways as a Target for the Treatment of Liver Diseases
Mini-Reviews in Medicinal Chemistry Update on Childhood Brucellosis
Recent Patents on Anti-Infective Drug Discovery Current Evidence and Future Perspectives on Anti-platelet and Statin Pharmacotherapy for Patients with Symptomatic Peripheral Arterial Disease
Current Vascular Pharmacology The Risks and Benefits of Therapy with Aldosterone Receptor Antagonist Therapy
Current Drug Safety Pharmacological Potential of Tetrahydrofurano/Pyrano Quinoline and Benzo[b]furoindolyl Derivatives in Acute Inflammation, Pain and Oxidative Stress
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry A Review of Premature Frailty in HIV-Infected Persons; Another Manifestation of HIV-Related Accelerated Aging
Current Aging Science Impact of Diabetes in Blood-Testis and Blood-Brain Barriers: Resemblances and Differences
Current Diabetes Reviews Design and Synthesis of 2-(Arylmethylideneamino) Isoindolines as New Potential Analgesic and Anti-Inflammatory Agents: A Molecular Hybridization Approach
Current Pharmaceutical Design Mechanisms of Improvement of Left Ventricular Function by Intracoronary Human Umbilical Cord-Derived Mesenchymal Stem Cell Infusion in Very Old Patients with Coronary Chronic Total Occlusion
Current Pharmaceutical Design Aminophosphonic Acids of Potential Medical Importance
Current Medicinal Chemistry - Anti-Cancer Agents Fertility Drugs and Ovarian Cancer
Current Cancer Drug Targets 1,2,4-Triazine Chemistry Part III: Synthetic Strategies to Functionalized Bridgehead Nitrogen Heteroannulated 1,2,4-Triazine Systems and their Regiospecific and Pharmacological Properties
Current Organic Synthesis Predictive Biomarkers and Novel Targets in the Treatment of Metastatic Renal Cell Carcinoma
Current Medicinal Chemistry Aqueous Two-phase Extraction in Downstream Processing
Current Biochemical Engineering (Discontinued) Transcriptional Regulation of the Heme Oxygenase-1 Gene Via the Stress Response Element Pathway
Current Pharmaceutical Design Pharmacogenetics Research Developments in Africa: A Focus on Malawi
Current Pharmacogenomics and Personalized Medicine