Ribozymes, DNAzymes and Small Interfering RNAs as Therapeutics

Title: Ribozymes, DNAzymes and Small Interfering RNAs as Therapeutics

Volume: 6 Issue: 6

Author(s): M. Sioud and P. O. Iversen

Affiliation:

Keywords: dnazyme, ribozyme. rna interference, small interfering rnas

Abstract: Selective gene silencing by nucleic acid enzymes has provided researchers with a new strategy to block gene expression and drug target validation. Ribozymes, DNAzymes and small interfering RNAs (siRNAs) are being explored as genetic inhibitors of gene expression as well as potential therapeutics against viral infections, inflammatory disorders, haematological diseases and cancers. We review the mode of action of these molecules, with special emphasis on their construction and the possibility to enhance their serum half-lives via specific chemical modifications. Their potential use in cell cultures and in animal models for disease is also highlighted.

Cite this article as:

Sioud M. and Iversen O. P., Ribozymes, DNAzymes and Small Interfering RNAs as Therapeutics, Current Drug Targets 2005; 6 (6) . https://dx.doi.org/10.2174/1389450054863653