Synthesis and In vitro Evaluation of Dibenzoazepine Triazole Derivatives: A Novel Class of Antileishmanial Agents

Title:Synthesis and In vitro Evaluation of Dibenzoazepine Triazole Derivatives: A Novel Class of Antileishmanial Agents

Volume: 12 Issue: 7

Author(s): Maria Aqeel Khan, Aliyan Saleem, Nida Ghouri, Abdul Hameed, M. Iqbal Choudhary and Fatima Z. Basha

Affiliation:

Keywords: Dibenzoazepine, iminostilbene, antileishmanial, click chemistry, immunomodulatory, triazoles.

Abstract: In the present study, a series of dibenzoazepine triazole derivatives (24-39) were synthesized and evaluated for their in vitro bioactivities including antiglycation, antibacterial, DPPH radical scavenging, urease inhibition, antileishmanial and immunomodulatory activities. The compounds were found to be moderately active only against leishmania. Within this series, compound 26 was found to be the most active antileishaminals with IC₅₀ value 37.4 ± 0.4 µM. Structure-activity relationships for this novel class are discussed.

Cite this article as:

Aqeel Khan Maria, Saleem Aliyan, Ghouri Nida, Hameed Abdul, Choudhary Iqbal M. and Basha Z. Fatima, Synthesis and In vitro Evaluation of Dibenzoazepine Triazole Derivatives: A Novel Class of Antileishmanial Agents, Letters in Drug Design & Discovery 2015; 12 (7) . https://dx.doi.org/10.2174/1570180812999150225111959

DOI https://dx.doi.org/10.2174/1570180812999150225111959	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X