Abstract
Neurodevelopmental disorders (NDs) are currently thought to be caused by either genetic defects or various environmental factors. Recent studies have demonstrated that congenital NDs can result not only from changes in DNA sequence in neuronal genes but also from changes to the secondary epigenomic modifications of DNA and histone proteins. Thus, epigenomic assays, as well as genomic assays, are currently performed for diagnosis of the congenital NDs. It is recently known that the epigenomic modifications can be altered by various environmental factors, which potentially cause acquired NDs. Furthermore these alterations can potentially be restored taking advantage of use of reversibility in epigenomics. Therefore, epigenome-based early diagnosis and subsequent intervention, by using drugs that restore epigenomic alterations, will open up a new era of preemptive medicine for congenital and acquired NDs.
Keywords: Neurodevelopmental disorder, Autism, Epigenomics, DNA methylation, Acquired, Preemptive medicine.
Graphical Abstract
Current Genomics
Title:Epigenomic-Basis of Preemptive Medicine for Neurodevelopmental Disorders
Volume: 16 Issue: 3
Author(s): Takeo Kubota, Kunio Miyake, Natsuyo Hariya and Kazuki Mochizuki
Affiliation:
Keywords: Neurodevelopmental disorder, Autism, Epigenomics, DNA methylation, Acquired, Preemptive medicine.
Abstract: Neurodevelopmental disorders (NDs) are currently thought to be caused by either genetic defects or various environmental factors. Recent studies have demonstrated that congenital NDs can result not only from changes in DNA sequence in neuronal genes but also from changes to the secondary epigenomic modifications of DNA and histone proteins. Thus, epigenomic assays, as well as genomic assays, are currently performed for diagnosis of the congenital NDs. It is recently known that the epigenomic modifications can be altered by various environmental factors, which potentially cause acquired NDs. Furthermore these alterations can potentially be restored taking advantage of use of reversibility in epigenomics. Therefore, epigenome-based early diagnosis and subsequent intervention, by using drugs that restore epigenomic alterations, will open up a new era of preemptive medicine for congenital and acquired NDs.
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Cite this article as:
Kubota Takeo, Miyake Kunio, Hariya Natsuyo and Mochizuki Kazuki, Epigenomic-Basis of Preemptive Medicine for Neurodevelopmental Disorders, Current Genomics 2015; 16 (3) . https://dx.doi.org/10.2174/1389202916666150216221312
DOI https://dx.doi.org/10.2174/1389202916666150216221312 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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