蛋白质精氨酸脱亚胺酶和相关瓜氨酸化：调节异常相关的生理功能和疾病

Title:Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation

Volume: 16 Issue: 7

Author(s): Erin E. Witalison, Paul R. Thompson and Lorne J. Hofseth

Affiliation:

关键词: 细胞凋亡，自身免疫性疾病，瓜氨酸化，基因调节，炎症性疾病，蛋白质精氨酸脱亚胺酶。

摘要: Human proteins are subjected to more than 200 known post-translational modifications (PTMs) (e.g., phosphorylation, glycosylation, ubiquitination, S-nitrosylation, methylation, Nacetylation, and citrullination) and these PTMs can alter protein structure and function with consequent effects on the multitude of pathways necessary for maintaining the physiological homeostasis. When dysregulated, however, the enzymes that catalyze these PTMs can impact the genesis of countless diseases. In this review, we will focus on protein citrullination, a PTM catalyzed by the Protein Arginine Deiminase (PAD) family of enzymes. Specifically, we will describe the roles of the PADs in both normal human physiology and disease. The development of PAD inhibitors and their efficacy in a variety of autoimmune disorders and cancer will also be discussed.

Cite this article as:

Erin E. Witalison, Paul R. Thompson and Lorne J. Hofseth , Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation, Current Drug Targets 2015; 16 (7) . https://dx.doi.org/10.2174/1389450116666150202160954