心血管健康和疾病中的OPA1

Title:OPA1 in Cardiovascular Health and Disease

Volume: 16 Issue: 8

Author(s): Niall Burke, Andrew R. Hall and Derek J. Hausenloy

Affiliation:

关键词: 心血管疾病，裂变，融合，线粒体形态学，视神经萎缩蛋白1

摘要: Mitochondria are known to play crucial roles in normal cellular physiology and in more recent years they have been implicated in a wide range of pathologies. Central to both these roles is their ability to alter their shape interchangeably between two different morphologies: an elongated interconnected network and a fragmented discrete phenotype - processes which are under the regulation of the mitochondrial fusion and fission proteins, respectively. In this review article, we focus on the mitochondrial fusion protein optic atrophy protein 1 (OPA1) in cardiovascular health and disease and we explore its role as a potential therapeutic target for treating cardiovascular and metabolic disease.

Cite this article as:

Niall Burke, Andrew R. Hall and Derek J. Hausenloy , OPA1 in Cardiovascular Health and Disease, Current Drug Targets 2015; 16 (8) . https://dx.doi.org/10.2174/1389450116666150102113648