Sol-gel Encapsulation of Biomolecules and Cells for Medicinal Applications

Title:Sol-gel Encapsulation of Biomolecules and Cells for Medicinal Applications

Volume: 15 Issue: 3

Author(s): Xiaolin Wang, Nada Ben Ahmed, Gisela S. Alvarez, Maria V. Tuttolomondo, Christophe Helary, Martin F. Desimone and Thibaud Coradin

Affiliation:

Keywords: Bioreactors, Biosensors, Delivery, Drug, Encapsulation, Sol-gel, Tissue engineering.

Abstract: The sol-gel process provides a robust and versatile technology for the immobilization of biologicals. A wide range of inorganic, composites and hybrid materials can be prepared to encapsulate molecular drugs, proteins, antibodies/antigens, enzymes, nucleic acids, prokaryotic and eukaryotic cells into bulk gels, particles and films. This review describes the applications of sol-gel encapsulation relevant to medicinal chemistry focusing on the recent development of biosensors as well as systems for production, screening and delivery of bioactive compounds and biomaterials.

Cite this article as:

Wang Xiaolin, Ahmed Ben Nada, Alvarez S. Gisela, Tuttolomondo V. Maria, Helary Christophe, Desimone F. Martin and Coradin Thibaud, Sol-gel Encapsulation of Biomolecules and Cells for Medicinal Applications, Current Topics in Medicinal Chemistry 2015; 15 (3) . https://dx.doi.org/10.2174/1568026614666141229112734