The Impact of Nandrolone Decanoate on the Central Nervous System

Title:The Impact of Nandrolone Decanoate on the Central Nervous System

Volume: 13 Issue: 1

Author(s): Francesco P. Busardo, Paola Frati, Mariantonia Di Sanzo, Simona Napoletano, Enrica Pinchi, Simona Zaami and Vittorio Fineschi

Affiliation:

Keywords: Nandrolone decanoate (ND), Anabolic androgenic steroids (AAS), neurological effects, anxiety, aggression, learning and memory.

Abstract: Nandrolone is included in the class II of anabolic androgenic steroids (AAS) which is composed of 19-nor-testosterone-derivates. In general, AAS is a broad and rapidly increasing group of synthetic androgens used both clinically and illicitly. AAS in general and nandrolone decanoate (ND) in particular have been associated with several behavioral disorders. The purpose of this review is to summarize the literature concerning studies dealing with ND exposure on animal models, mostly rats that mimic human abuse systems (i.e. supraphysiological doses). We have focused in particular on researches that have investigated how ND alters the function and expression of neuronal signaling molecules that underlie behavior, anxiety, aggression, learning and memory, reproductive behaviors, locomotion and reward.

Cite this article as:

Busardo P. Francesco, Frati Paola, Di Sanzo Mariantonia, Napoletano Simona, Pinchi Enrica, Zaami Simona and Fineschi Vittorio, The Impact of Nandrolone Decanoate on the Central Nervous System, Current Neuropharmacology 2015; 13 (1) . https://dx.doi.org/10.2174/1570159X13666141210225822