激活的内源性大麻素系统在动脉粥样硬化中是驱动力还是保护机制？

Title:The Activated Endocannabinoid System in Atherosclerosis: Driving Force or Protective Mechanism?

Volume: 16 Issue: 4

Author(s): Sabine Steffens and Pal Pacher

Affiliation:

关键词: 大麻素受体CB1，CB2，甘油二酯脂肪酶，类花生酸，脂肪酸酰胺水解酶，单酰基甘油脂肪酶。

摘要: Atherosclerosis and its major acute complications, myocardial infarction and stroke, are the leading causes of death and morbidity worldwide. Despite major advances in cardiovascular intervention and healthcare, improving preventive care and treatment remains a continuous mission for cardiovascular research. Within the last 10 to 15 years, the endocannabinoid system has emerged as an important lipid signaling system involved in many biological processes. Growing evidence suggests that an overactive endocannabinoid-CB₁ receptor signaling promotes the development of cardiovascular risk factors such as obesity, insulin resistance and dyslipidemia. This prompted an increasing interest in studying the role of the endocannabinoid system in atherosclerosis. As opposed to the detrimental actions of CB₁ signaling, the endocannabinoid-CB₂ receptor axis exhibits an anti-inflammatory and atheroprotective role. We will review recent findings from experimental and clinical studies aimed at understanding the complex actions of endocannabinoid signaling in cardiovascular disease. This is followed by an outlook on emerging targets for possible therapeutic intervention.

Cite this article as:

Sabine Steffens and Pal Pacher , The Activated Endocannabinoid System in Atherosclerosis: Driving Force or Protective Mechanism?, Current Drug Targets 2015; 16 (4) . https://dx.doi.org/10.2174/1389450115666141202113225