Synthesis and Antitubercular Screening of Some Novel 4H-1,4- Benzothiazines and their Sulfones Under Environment Benign Solvent Free Conditions as Future Anti-Tubercular Agents

Title:Synthesis and Antitubercular Screening of Some Novel 4H-1,4- Benzothiazines and their Sulfones Under Environment Benign Solvent Free Conditions as Future Anti-Tubercular Agents

Volume: 18 Issue: 1

Author(s): Anjali Guleria, Dinesh K. Jangid, Naveen Gautam, Richa Lakhotia, Abhay Chowdhary and Dinesh C. Gautam

Affiliation:

Keywords: 4H-1, 4-benzothiazines, antitubercular agents, green chemistry, REMA, sulfones.

Abstract: Some novel analogs of 4H-1,4-benzothiazines were synthesized under environmentally benign solvent free conditions by one pot oxidative cyclocondensation of substituted 2- aminobenzenthiols with compounds having active methylene group and then converted in to sulfones. These compounds were examined as antitubercular agents against Mycobacterium tuberculosis H37Rv using REMA plate method. The best results have MICs from 6.4 to 8.8 μg/mL, comparable to phenothiazines. IR, NMR and mass spectral investigations are included for structural elucidation.

Cite this article as:

Guleria Anjali, K. Jangid Dinesh, Gautam Naveen, Lakhotia Richa, Chowdhary Abhay and C. Gautam Dinesh, Synthesis and Antitubercular Screening of Some Novel 4H-1,4- Benzothiazines and their Sulfones Under Environment Benign Solvent Free Conditions as Future Anti-Tubercular Agents, Combinatorial Chemistry & High Throughput Screening 2015; 18 (1) . https://dx.doi.org/10.2174/1386207317666141126164147