阴茎持续勃起症的分子病理生理学：新兴的靶点

Title:Molecular Pathophysiology of Priapism: Emerging Targets

Volume: 16 Issue: 5

Author(s): Uzoma A. Anele, Belinda F. Morrison and Arthur L. Burnett

Affiliation:

关键词: 腺苷，一氧化氮，opiorphins，rho激酶，复发性缺血性阴茎持续勃起症治疗，睾丸素

摘要: Priapism is an erectile disorder involving uncontrolled, prolonged penile erection without sexual purpose, which can lead to erectile dysfunction. Ischemic priapism, the most common of the variants, occurs with high prevalence in patients with sickle cell disease. Despite the potentially devastating complications of this condition, management of recurrent priapism episodes historically has commonly involved reactive treatments rather than preventative strategies. Recently, increasing elucidation of the complex molecular mechanisms underlying this disorder, principally involving dysregulation of nitric oxide signaling, has allowed for greater insights and exploration into potential therapeutic targets. In this review, we discuss the multiple molecular regulatory pathways implicated in the pathophysiology of priapism. We also identify the roles and mechanisms of molecular effectors in providing the basis for potential future therapies.

Cite this article as:

Uzoma A. Anele, Belinda F. Morrison and Arthur L. Burnett , Molecular Pathophysiology of Priapism: Emerging Targets, Current Drug Targets 2015; 16 (5) . https://dx.doi.org/10.2174/1389450115666141111111842