Role of microRNAs in Osteoblasts Differentiation and Bone Disorders

Title:Role of microRNAs in Osteoblasts Differentiation and Bone Disorders

Volume: 22 Issue: 6

Author(s): Yasir Arfat, Wei-Zhong Xiao, Munazza Ahmad, Fan Zhao, Di-Jie Li, Yu-Long Sun, Lifang Hu, Chen Zhihao, Ge Zhang, Salman Iftikhar, Peng Shang, Tuan-Ming Yang and Ai-Rong Qian

Affiliation:

Keywords: Bone disorder, microRNAs, osteoblasts differentiation, signaling pathways.

Abstract: Advanced studies of single stranded endogenous ~22 nt microRNAs (miRNAs) have demonstrated their diverse biological functions including control of cell differentiation, cell cycle and pathological conditions. Recent studies suggest the potential application of miRNAs in stem cell engineering. miRNAs play a vital role as post-transcriptional regulators of gene expression which controls osteoblasts-mediated bone formation and osteoclasts related bone remodeling. Transcriptional and post-transcriptional mechanisms regulate the differentiation of osteoblasts and osteogenesis. The differentiation of osteoblasts is a key step in the development of skeletal muscles and it is involved in triggering the signaling pathways. Signaling pathways like TGFβ, BMP and Wnt are regulated by miRNAs which in turn, are shown to be associated with bone dynamics and bone disorders. This recap highlights the role of miRNAs in osteoblasts differentiation and emphasizes their potential therapeutic role in metabolic bone disorders.

Cite this article as:

Arfat Yasir, Xiao Wei-Zhong, Ahmad Munazza, Zhao Fan, Li Di-Jie, Sun Yu-Long, Hu Lifang, Zhihao Chen, Zhang Ge, Iftikhar Salman, Shang Peng, Yang Tuan-Ming and Qian Ai-Rong, Role of microRNAs in Osteoblasts Differentiation and Bone Disorders, Current Medicinal Chemistry 2015; 22 (6) . https://dx.doi.org/10.2174/0929867321999141106121227