Mast Cells in Lung Homeostasis: Beyond Type I Hypersensitivity

Title:Mast Cells in Lung Homeostasis: Beyond Type I Hypersensitivity

Volume: 10 Issue: 2

Author(s): Marcia Campillo-Navarro, Alma D. Chavez-Blanco, Isabel Wong-Baeza, Jeanet Serafín-Lopez, Raul Flores-Mejia, Sergio Estrada-Parra, Iris Estrada-Garcia and Rommel Chacon-Salinas

Affiliation:

Keywords: Allergic inflammation, cancer, lungs, mast cells, pathogens, wound healing.

Abstract: Lungs are indispensable organs for the respiratory process, and maintaining their homeostasis is essential for human health and survival. However, during the lifetime of an individual, the lungs suffer countless insults that put at risk their delicate organization and function. Many cells of the immune system participate to maintain this equilibrium and to keep functional lungs. Among these cells, mast cells have recently attracted attention because of their ability to rapidly secrete many chemical and biological mediators that modulate different processes like inflammation, angiogenesis, cell proliferation, etc. In this review, we focus on recent advances in the understanding of the role that mast cells play in lung protection during infections, and of the relation of mast cell responses to type I hypersensitivity-associated pathologies. Furthermore, we discuss the potential role of mast cells during wound healing in the lung and its association with lung cancer, and how mast cells could be exploited as therapeutic targets in some diseases.

Cite this article as:

Campillo-Navarro Marcia, Chavez-Blanco D. Alma, Wong-Baeza Isabel, Serafín-Lopez Jeanet, Flores-Mejia Raul, Estrada-Parra Sergio, Estrada-Garcia Iris and Chacon-Salinas Rommel, Mast Cells in Lung Homeostasis: Beyond Type I Hypersensitivity, Current Respiratory Medicine Reviews 2014; 10 (2) . https://dx.doi.org/10.2174/1573398X10666141024220151