绿茶多酚儿茶素没食子酸盐的血管和代谢作用

Title:Vascular and Metabolic Actions of the Green Tea Polyphenol Epigallocatechin Gallate

Volume: 22 Issue: 1

Author(s): Michelle A. Keske, Huei L.H. Ng, Dino Premilovac, Stephen Rattigan, Jeong-a Kim, Kashif Munir, Peixin Yang and Michael J. Quon

Affiliation:

关键词: 儿茶素没食子酸盐，内皮功能，绿茶，胰岛素作用，胰岛素敏感性，代谢，肌肉血流量，2型糖尿病。

摘要: Epidemiological studies demonstrate robust correlations between green tea consumption and reduced risk of type 2 diabetes and its cardiovascular complications. However, underlying molecular, cellular, and physiological mechanisms remain incompletely understood. Health promoting actions of green tea are often attributed to epigallocatechin gallate (EGCG), the most abundant polyphenol in green tea. Insulin resistance and endothelial dysfunction play key roles in the pathogenesis of type 2 diabetes and its cardiovascular complications. Metabolic insulin resistance results from impaired insulin-mediated glucose disposal in skeletal muscle and adipose tissue, and blunted insulin-mediated suppression of hepatic glucose output that is often associated with endothelial/ vascular dysfunction. This endothelial dysfunction is itself caused, in part, by impaired insulin signaling in vascular endothelium resulting in reduced insulin-stimulated production of NO in arteries, and arterioles that regulate nutritive capillaries. In this review, we discuss the considerable body of literature supporting insulin-mimetic actions of EGCG that oppose endothelial dysfunction and ameliorate metabolic insulin resistance in skeletal muscle and liver. We conclude that EGCG is a promising therapeutic to combat cardiovascular complications associated with the metabolic diseases characterized by reciprocal relationships between insulin resistance and endothelial dysfunction that include obesity, metabolic syndrome and type 2 diabetes. There is a strong rationale for well-powered randomized placebo controlled intervention trials to be carried out in insulin resistant and diabetic populations.

Cite this article as:

Michelle A. Keske, Huei L.H. Ng, Dino Premilovac, Stephen Rattigan, Jeong-a Kim, Kashif Munir, Peixin Yang and Quon J. Michael, Vascular and Metabolic Actions of the Green Tea Polyphenol Epigallocatechin Gallate, Current Medicinal Chemistry 2015; 22 (1) . https://dx.doi.org/10.2174/0929867321666141012174553