Defensins and Other Antimicrobial Peptides: A Historical Perspective and an Update

Tomas      Ganz

doi:10.2174/1386207053764594

Abstract

Antimicrobial peptides are effectors of innate immunity in phagocytes, body fluids and epithelia. In mammals, defensins, peptides with a characteristic six-cysteine framework, are particularly abundant and widely distributed in various animal species and tissues. The first part of this review provides a historical overview of the ideas that led to the current state-of-the-art in antimicrobial peptides, and the second part is an update on mammalian defensins and their role in host defense to infections.

Keywords: history, membrane interactions, peptide structure

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Combinatorial Chemistry & High Throughput Screening

Title: Defensins and Other Antimicrobial Peptides: A Historical Perspective and an Update

Volume: 8 Issue: 3

Author(s): Tomas Ganz

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Keywords: history, membrane interactions, peptide structure

Abstract: Antimicrobial peptides are effectors of innate immunity in phagocytes, body fluids and epithelia. In mammals, defensins, peptides with a characteristic six-cysteine framework, are particularly abundant and widely distributed in various animal species and tissues. The first part of this review provides a historical overview of the ideas that led to the current state-of-the-art in antimicrobial peptides, and the second part is an update on mammalian defensins and their role in host defense to infections.

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Ganz Tomas, Defensins and Other Antimicrobial Peptides: A Historical Perspective and an Update, Combinatorial Chemistry & High Throughput Screening 2005; 8 (3) . https://dx.doi.org/10.2174/1386207053764594