miR-205在正常的生理，癌症和作为一个潜在治疗靶点的重要作用

Title:The Important Roles of miR-205 in Normal Physiology, Cancers and as a Potential Therapeutic Target

Volume: 14 Issue: 7

Author(s): Haleh Vosgha, Ali Salajegheh, Robert Anthony Smith and Alfred King-Yin Lam

Affiliation:

关键词: 许多证据表明microRNA-205（MIR-205）在正常的生理中的关键调解作用以及其在许多癌症中的异常表达。事实上，miR-205已经被证实为既是抑制肿瘤也是致癌的miRNA，通过调节不同细胞通路例如细胞存活、凋亡、血管生成和转移在肿瘤发生中扮演重要角色。作为肿瘤抑制基因， miR-205可作为细胞的增殖、迁移和侵袭的抑制剂；另一方面，作为致癌基因，miR-205促进肿瘤发生和发展；在多种类型的癌症中作用于不同靶基因实现所有这些功能。同时，miR-205也展示了其作为多种癌症治疗靶标的潜力。总的来说，miR-205在不同癌症中有重要的临床和药理相关性，并作为诊断和预后的标志物以及癌症治疗的新的分子靶标。 癌，癌症，miRNA-205

摘要: Evidences have demonstrated key mediatory roles of microRNA-205 (miR-205) in normal physiology and its aberrant expression in many cancers. Indeed, miR-205 has been identified as both a tumour suppressive and oncogenic miRNA playing crucial roles in tumourigenesis through regulating different cellular pathways such as cell survival, apoptosis, angiogenesis and metastasis. As a tumour suppressor, miR-205 acts as an inhibitor of cell proliferation, migration and invasion. On the other hand, as an oncogene, miR-205 promotes tumour initiation and development. All these functions act through different target genes in various types of cancers. Also, miR-205 displays potential as a therapeutic target for different cancers. To conclude, miR-205 has important clinical and pathological correlations in different cancers and may act as a diagnostic and prognostic marker as well as new molecular target for cancer therapy.

Cite this article as:

Vosgha Haleh, Salajegheh Ali, Smith Anthony Robert and Lam King-Yin Alfred, The Important Roles of miR-205 in Normal Physiology, Cancers and as a Potential Therapeutic Target, Current Cancer Drug Targets 2014; 14 (7) . https://dx.doi.org/10.2174/156800961407140926105634