PfalDB:恶性疟原虫的一种综合药物靶点和化学数据库

Title:PfalDB: An Integrated Drug Target and Chemical Database for Plasmodium flaciparum

Volume: 15 Issue: 12

Author(s): Amit Kumar, Nidhi Agarwal, Lalit Pant, Jay Prakash Singh, Indira Ghosh and Naidu Subbarao

Affiliation:

关键词: 抗疟，数据库，药物靶标，抑制剂，选择性

摘要: Plasmodium falciparum is one of the deadliest protozoan parasite species among those that cause malaria. Uncontrolled use of antimalarial drugs has resulted in evolutionary selection pressure favoring high levels of resistance to antimalarials; currently P.falciparum shows resistance to all classes of antimalarials. Therefore it is essential to identify novel drug targets, and design selective anti-malarials which can overcome resistance. While many drug targets are freely available in various public domain resources, a single comprehensive source of data containing easily searchable and retrievable information is currently lacking. To facilitate the total integration and mining of data emerging from different drug consortia and also to prioritize drug targets for structure-based drug design, an open-access, inclusive comprehensive database for Plasmodium falciparum was established. Meta data of known/modeled structures along with binding site parameters of drug targets have been included in the database. Additionally, chemical compounds showing a positive inhibitory assay against Plasmodium falciparum or known drug targets have also been provided. The database is accessible at http://pfaldb.jnu.ac.in. The database provides diverse information regarding the structure, sequence, stage specific gene expression, pathway, action mechanism, essentiality and druggability for each drug target, and literature to assess the validation status of individual drug targets. It also includes information on individual anti-malarials with their activity and bioassay.

Cite this article as:

Kumar Amit, Agarwal Nidhi, Pant Lalit, Singh Prakash Jay, Ghosh Indira and Subbarao Naidu, PfalDB: An Integrated Drug Target and Chemical Database for Plasmodium flaciparum, Current Drug Targets 2014; 15 (12) . https://dx.doi.org/10.2174/1389450115666140908114939