β-肾上腺素过度刺激和心肌细胞凋亡：同一细胞器中的两种受体，两种命运？

Title:β-Adrenergic Over-Stimulation and Cardio-Myocyte Apoptosis: Two Receptors, One Organelle, Two Fates?

Volume: 15 Issue: 10

Author(s): Ana F. Branco, Ana C. Moreira, Teresa Cunha-Oliveira, Renata Couto, Vilma A. Sardao, Albert A. Rizvanov, Andras Palotas and Paulo J. Oliveira

Affiliation:

关键词: 细胞凋亡，α-肾上腺素能受体，钙，心肌细胞，线粒体，氧化应激

摘要: Neuro-hormonal regulation of cardiac function via cathecol-amines results in increased heart rate and contractility. A persistent adrenergic tone, however, is an insult to the heart, affecting its regular homeostasis, altering morphology and gene expression patterns, as well as inducing apoptosis of cardio-myocytes. At the same time as being the main oxygen consumers, mitochondria are also key to the energy production required for the heart to maintain its vital functions and to integrate a series of signaling pathways that define the life and death of the cell. As α-adrenergic receptors (α-AR) orchestrate multiple biochemical events that can either trigger or inhibit cell death, mitochondria can act as a referee in the entire process. In fact, α-AR subtypes α₁ and α₂ activate various down-stream pathways which differently modulate intracellular calcium levels and production of mitochondrial reactive oxygen species (ROS). The delicate balance between an adaptive (cardio-protective) response resulting in increased contractility and activation of survival pathways, vs. cell death caused by calcium and ROS-induced mitochondrial disruption, along with evidence of their clinical and potential therapeutic translations, are reviewed in this communication.

Cite this article as:

Branco F. Ana, Moreira C. Ana, Cunha-Oliveira Teresa, Couto Renata, Sardao A. Vilma, Rizvanov A. Albert, Palotas Andras and Oliveira J. Paulo, β-Adrenergic Over-Stimulation and Cardio-Myocyte Apoptosis: Two Receptors, One Organelle, Two Fates?, Current Drug Targets 2014; 15 (10) . https://dx.doi.org/10.2174/1389450115666140902124230