针对下一代腺苷A2A受体拮抗剂

Title:Towards Next Generation Adenosine A_2A Receptor Antagonists

Volume: 21 Issue: 34

Author(s): G. Yuan and G.B. Jones

Affiliation:

关键词: A2AR拮抗剂、水溶解性、癌症免疫疗法、分子模型、 帕金森氏病、PET成像、 X-射线晶体学

摘要: The Adenosine A2A receptor is a member of the G-protein coupled receptor superfamily. It plays a key role in numerous physiological processes through the central nervous system and in peripheral tissues. Functional interactions between the A2A and dopamine D2 receptor has spurred interest in the use of antagonists as anti-Parkinson drugs. Additionally, oncology drugs are now being designed based on the potential for A2A antagonists to function as immunotherapeutics. From early studies based on classical xanthine type A2A antagonists through second generation agents, this mini review will cover aspects of the discovery, development, chemical synthesis and medicinal evaluation of this important class of drugs.

Cite this article as:

Yuan G. and Jones G.B., Towards Next Generation Adenosine A_2A Receptor Antagonists, Current Medicinal Chemistry 2014; 21 (34) . https://dx.doi.org/10.2174/0929867321666140826115123