Abstract
Progress in cancer treatment remains challenging because of the great nature of tumor cells to be drug resistant. However, advances in the field of nanotechnology have enabled the delivery of drugs for cancer treatment by passively and actively targeting to tumor cells with nanoparticles. Dramatic improvements in nanotherapeutics, as applied to cancer, have rapidly accelerated clinical investigations. In this review, drug-targeting systems using nanotechnology and approved and clinically investigated nanoparticles for cancer therapy are discussed. In addition, the rationale for a nanotechnological approach to cancer therapy is emphasized because of its promising advances in the treatment of cancer patients.
Keywords: Cancer, drug delivery, drug, nanoparticles, nanotechnology, polimeric, targeting, therapeutics.
Mini-Reviews in Medicinal Chemistry
Title:Drug Targeting Systems for Cancer Therapy: Nanotechnological Approach
Volume: 14 Issue: 13
Author(s): R. Seda Tigli Aydin
Affiliation:
Keywords: Cancer, drug delivery, drug, nanoparticles, nanotechnology, polimeric, targeting, therapeutics.
Abstract: Progress in cancer treatment remains challenging because of the great nature of tumor cells to be drug resistant. However, advances in the field of nanotechnology have enabled the delivery of drugs for cancer treatment by passively and actively targeting to tumor cells with nanoparticles. Dramatic improvements in nanotherapeutics, as applied to cancer, have rapidly accelerated clinical investigations. In this review, drug-targeting systems using nanotechnology and approved and clinically investigated nanoparticles for cancer therapy are discussed. In addition, the rationale for a nanotechnological approach to cancer therapy is emphasized because of its promising advances in the treatment of cancer patients.
Export Options
About this article
Cite this article as:
Tigli Aydin Seda R., Drug Targeting Systems for Cancer Therapy: Nanotechnological Approach, Mini-Reviews in Medicinal Chemistry 2014; 14 (13) . https://dx.doi.org/10.2174/1389557514666140820115052
DOI https://dx.doi.org/10.2174/1389557514666140820115052 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Genistein Down-Regulates miR-223 Expression in Pancreatic Cancer Cells
Current Drug Targets Distribution and Characteristics of Intrathoracic Lymphadenopathy in TB/HIV Co-Infection
Infectious Disorders - Drug Targets Regulators of Chemokine Receptor Activity as Promising Anticancer Therapeutics
Current Cancer Drug Targets Natural Killer Cells Preferentially Target Cancer Stem Cells; Role of Monocytes in Protection Against NK Cell Mediated Lysis of Cancer Stem Cells
Current Drug Delivery Neddylation Pathway as a Novel Anti-cancer Target: Mechanistic Investigation and Therapeutic Implication
Anti-Cancer Agents in Medicinal Chemistry It Takes Two to Tango: The Structure and Function of LIM, RING, PHD and MYND Domains
Current Pharmaceutical Design Epstein-Barr Virus-associated Gastric Cancer and Potential Mechanisms of Oncogenesis
Current Cancer Drug Targets Effect of Liposomes with Different Double Arms Polyethyleneglycol on Hepatic Metastasis Model Mice and Evaluation Using a Fluorescent Imaging Device
Current Drug Delivery Current Status and Perspectives in Peptide Receptor Radiation Therapy
Current Pharmaceutical Design mRNA as a Versatile Tool for Exogenous Protein Expression
Current Gene Therapy Protein Kinases as Tumor Biomarkers and Therapeutic Targets
Current Pharmaceutical Design Roles of p97-Associated Deubiquitinases in Protein Quality Control at the Endoplasmic Reticulum
Current Protein & Peptide Science Approaches for Administering Chemotherapy in the Intensive Care Unit
Current Drug Safety Biotechnological Engineering of Heparin/Heparan Sulphate: A Novel Area of Multi-Target Drug Discovery
Current Pharmaceutical Design Design, Synthesis and Biological Evaluation of Hybrid Molecules Containing Conjugated Styryl Ketone and α-Bromoacryloyl Moieties
Letters in Drug Design & Discovery Targeting Heme for the Identification of Cytotoxic Agents
Anti-Cancer Agents in Medicinal Chemistry Killing the Messenger: Antisense DNA and siRNA
Current Drug Targets Applied Proteomics in Companion Animal Medicine
Current Proteomics Reversing Agents for ATP-Binding Cassette (ABC) Transporters: Application in Modulating Multidrug Resistance (MDR)
Current Medicinal Chemistry - Anti-Cancer Agents Fibrates in the Chemical Action of Daunorubicin
Current Cancer Drug Targets