Ferroquine as an Oxidative Shock Antimalarial

Title:Ferroquine as an Oxidative Shock Antimalarial

Volume: 14 Issue: 14

Author(s): Daniel Dive and Christophe Biot

Affiliation:

Keywords: Malaria, ferroquine, mechanism of action, hydrogen bond, redox behavior.

Abstract: Over the course of the development of the antimalarial ferroquine, we have developed many ideas about its specific mechanism of action. Those ideas have enabled us to propose several experiments to control the validity of these hypotheses concerning differences between ferroquine and chloroquine and their respective mechanisms of action. We have now established an ultimate theory reconciling the hydrogen bond and the redox mechanisms hypotheses of ferroquine and fitting a wider range of published experimental results.

Cite this article as:

Dive Daniel and Biot Christophe, Ferroquine as an Oxidative Shock Antimalarial, Current Topics in Medicinal Chemistry 2014; 14 (14) . https://dx.doi.org/10.2174/1568026614666140808122329