Alcohol Enhances HIV Infection of Cord Blood Monocyte-Derived Macrophages

Title:Alcohol Enhances HIV Infection of Cord Blood Monocyte-Derived Macrophages

Volume: 12 Issue: 4

Author(s): Dimitrios S. Mastrogiannis, Xu Wang, Min Dai, Jieliang Li, Yizhong Wang, Yu Zhou, Selin Sakarcan, Juliet Crystal Pena and Wenzhe Ho

Affiliation:

Keywords: Alcohol, Anti-HIV miRNAs, Cord blood, Intracellular restriction factors, HIV.

Abstract: Alcohol consumption or alcohol abuse is common among pregnant HIV⁺ women and has been identified as a potential behavioral risk factor for the transmission of HIV. In this study, we examined the impact of alcohol on HIV infection of cord blood monocyte-derived macrophages (CBMDM). We demonstrated that alcohol treatment of CBMDM significantly enhanced HIV infection of CBMDM. Investigation of the mechanisms of alcohol action on HIV demonstrated that alcohol inhibited the expression of several HIV restriction factors, including anti-HIV microRNAs, APOBEC3G and APOBEC3H. Additionally, alcohol also suppressed the expression of IFN regulatory factor 7 (IRF-7) and retinoic acid-inducible gene I (RIG-I), an intracellular sensor of viral infection. The suppression of these IFN regulatory factors was associated with reduced expression of type I IFN. These experimental findings suggest that maternal alcohol consumption may facilitate HIV infection, promoting vertical transmission of HIV.

Cite this article as:

Mastrogiannis S. Dimitrios, Wang Xu, Dai Min, Li Jieliang, Wang Yizhong, Zhou Yu, Sakarcan Selin, Pena Crystal Juliet and Ho Wenzhe, Alcohol Enhances HIV Infection of Cord Blood Monocyte-Derived Macrophages, Current HIV Research 2014; 12 (4) . https://dx.doi.org/10.2174/1570162X12666140721124923