¹¹C-mHED for PET / CT: Principles of Synthesis, Methodology and First Clinical Applications

Title:¹¹C-mHED for PET / CT: Principles of Synthesis, Methodology and First Clinical Applications

Volume: 7 Issue: 2

Author(s): Rachele Bonfiglioli, Cristina Nanni, Cristian Martignani, Lucia Zanoni, Raffaele La Donna, Igor Diemberger, Giuseppe Boriani, Cinzia Pettinato, Gianmario Sambuceti, Stefano Fanti and Luigi Mansi

Affiliation:

Keywords: ¹¹C -meta-hydroxy-ephedrine, cardiac imaging, norepinephrine, sympathetic innervations.

Abstract: Alterations of the cardiac autonomic nervous system play an important role in the pathway of many heart diseases. Nuclear imaging tools have been demonstrated to be useful for global and regional assessment of myocardial innervation. We used ¹¹C-meta-hydroxy-ephedrine (¹¹C-mHED), a catecholamine analogue, as a radiotracer usable with a PET/CT scanner to study the cardiac sympathetic system. After a fast and automatic synthesis of mHED and its labeling with ¹¹C, we acquired cardiac images by using a PET/ CT scanner. In this paper we present our preliminary results showing the radiotracer bio-distribution in humans 10 minutes post injection. The present study assesses the feasibility of PET/CT with the radiolabeled catecholamine analogue (¹¹C-mHED) in order to determine sympathetic innervation in the human heart.

Cite this article as:

Bonfiglioli Rachele, Nanni Cristina, Martignani Cristian, Zanoni Lucia, Donna La Raffaele, Diemberger Igor, Boriani Giuseppe, Pettinato Cinzia, Sambuceti Gianmario, Fanti Stefano and Mansi Luigi, ¹¹C-mHED for PET / CT: Principles of Synthesis, Methodology and First Clinical Applications, Current Radiopharmaceuticals 2014; 7 (2) . https://dx.doi.org/10.2174/1874471007666140714111304