Anti-cancer Drug Discovery: Update and Comparisons in Yeast, Drosophila, and Zebrafish

Title:Anti-cancer Drug Discovery: Update and Comparisons in Yeast, Drosophila, and Zebrafish

Volume: 7

Author(s): Guangxun Gao, Liang Chen and Chuanshu Huang

Affiliation:

Keywords: Anti-cancer drug discovery, Drosophila, HTS, model organism, yeast, zebrafish.

Abstract: Discovery of novel cancer chemotherapeutics focuses on screening and identifying compounds that can target ‘cancer-specific’ biological processes while causing minimal toxicity to non-tumor cells. Alternatively, model organisms with highly conserved cancer-related cellular processes relative to human cells may offer new opportunities for anticancer drug discovery when combined with chemical screening. Some organisms used for chemotherapeutic discovery include yeast, Drosophila, and zebrafish which are similar in important ways relevant to cancer study but offer distinct advantages as well. Here, we describe these model attributes and the rationale for using them in cancer drug screening research.

Cite this article as:

Gao Guangxun, Chen Liang and Huang Chuanshu, Anti-cancer Drug Discovery: Update and Comparisons in Yeast, Drosophila, and Zebrafish, Current Molecular Pharmacology 2014; 7 (1) . https://dx.doi.org/10.2174/1874467207666140702113629