O-Benzyl-(S)-Serine, a New Chiral Selector for Ligand-Exchange Chromatography of Amino Acids

Title: O-Benzyl-(S)-Serine, a New Chiral Selector for Ligand-Exchange Chromatography of Amino Acids

Volume: 1 Issue: 1

Author(s): Benedetto Natalini, Roccaldo Sardella and Roberto Pellicciari

Affiliation:

Keywords: enantiomer separation, chiral mobile phase, chiral coated phase, hydrophobically coated phase

Abstract: O-Benzyl-(S)-serine is a new selector for chiral ligand-exchange chromatography which has proved to be effective in the analytical separation of some natural and unnatural underivatized amino acids with fair to good separation and resolution factors. Both chiral mobile phase (CMP) and hydrophobically coated chiral stationary phase (CSP) approaches were successfully employed. A not completely clarified mechanism of chiral recognition is discussed.

Cite this article as:

Natalini Benedetto, Sardella Roccaldo and Pellicciari Roberto, O-Benzyl-(S)-Serine, a New Chiral Selector for Ligand-Exchange Chromatography of Amino Acids, Current Analytical Chemistry 2005; 1 (1) . https://dx.doi.org/10.2174/1573411052948479