A Facile Synthesis of Differently Protected Cystathionines in Aqueous Solutions

Lei      Zhang; Xiangming      Zhu

doi:10.2174/0929866521666140626110653

Abstract

A simple method for the synthesis of differently protected cystathionines is described. Reaction of γ- bromohomoalanine with cysteine derivatives in an ethyl acetate/water two-phase system, which contains TBAHS and NaHCO₃, led to the desired protected cystathionines in very high to excellent yields. Apart from the high yields, the mild conditions and the ease of conducting the reactions are also attractive features for this procedure.

Keywords: Cystathionine, thioether, protecting group, phase-transfer catalysis.

« Previous Next »

Rights & Permissions Print Cite

Protein & Peptide Letters

Title:A Facile Synthesis of Differently Protected Cystathionines in Aqueous Solutions

Volume: 21 Issue: 10

Author(s): Lei Zhang and Xiangming Zhu

Affiliation:

Keywords: Cystathionine, thioether, protecting group, phase-transfer catalysis.

Abstract: A simple method for the synthesis of differently protected cystathionines is described. Reaction of γ- bromohomoalanine with cysteine derivatives in an ethyl acetate/water two-phase system, which contains TBAHS and NaHCO₃, led to the desired protected cystathionines in very high to excellent yields. Apart from the high yields, the mild conditions and the ease of conducting the reactions are also attractive features for this procedure.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Zhang Lei and Zhu Xiangming, A Facile Synthesis of Differently Protected Cystathionines in Aqueous Solutions, Protein & Peptide Letters 2014; 21 (10) . https://dx.doi.org/10.2174/0929866521666140626110653

DOI https://dx.doi.org/10.2174/0929866521666140626110653	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305