Abstract
The synthesis of a new non-cross-linked polystyrene supported cyclosulfamide chiral auxiliary is described. Asymmetric aldol reactions using this auxiliary proceeded with good yields and excellent stereoselectivities, which were comparable with those observed by using non-supported cyclosulfamide chiral auxiliary. Furthermore, recovery and recycling of this polymer supported chiral auxiliary have been successfully achieved without appreciable reduction in the yield or stereoselectivity.
Keywords: Asymmetric aldol reactions, chiral auxiliary, cyclosulfamide, non-cross-linked polystyrene, supported.
Graphical Abstract
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