Alpha-1 Adrenergic Antagonists Induced Severe Rhinitis in Patients with Benign Prostatic Hyperplasia

Title:Alpha-1 Adrenergic Antagonists Induced Severe Rhinitis in Patients with Benign Prostatic Hyperplasia

Volume: 9 Issue: 2

Author(s): Eduardo Shahar, Laila Nassar, Eynat Kedem and Gammal Hassoun

Affiliation:

Keywords: Benign prostatic hyperplasia (BPH), lower urinary tract symptoms (LUTS).

Abstract: The standard gold care medications for benign prostatic hyperplasia (BPH) are the alpha-1-adrenergic antagonists, they are an effective medications and are generally well tolerated. However, at this time, no data have been published concerning the development of severe rhinorrhea with a great impact on quality of life in patients treated with alpha-1-adrenergic antagonists. We report two men with BPH treated with two different alpha-adrenergic antagonists; alfuzosin and doxazocin. The naranjo quality scale documented a probable adverse drug reaction (score 7) between rhinorrhea and treatmenr with alpha-1-adrenergic antagonists. In conclusion we reported that alpha-1-adrenergic antagonists are able to induce rhinorrhea in patients with BPH.

Cite this article as:

Shahar Eduardo, Nassar Laila, Kedem Eynat and Hassoun Gammal, Alpha-1 Adrenergic Antagonists Induced Severe Rhinitis in Patients with Benign Prostatic Hyperplasia, Current Drug Safety 2014; 9 (2) . https://dx.doi.org/10.2174/1574886309666140527112408