Microwave-assisted Cycloaddition Reactions in Carbo- and Heterocyclic Chemistry

Title:Microwave-assisted Cycloaddition Reactions in Carbo- and Heterocyclic Chemistry

Volume: 18 Issue: 16

Author(s): Aziza Saber, Hamid Marzag, Rachid Benhida and Khalid Bougrin

Affiliation:

Keywords: [2+2] cycloaddition, 1, 3-dipolar cycloaddition, carbocycles, diels-alder, green catalysis, green chemistry, heterocycles, microwave synthesis.

Abstract: Recent developments in the microwave-assisted synthesis of carbo- and heterocyclicsystems are reviewed with the focus on diversity-oriented cycloaddition reactions. Ineed, these reactions represent one of the most important endeavors in chemistry and are of considerable interest in the synthesis of carbo-and heterocyclic compounds from simple unsaturated systems, and allow the creation of more than two bonds in one step. This review summarizes recent literature (2006-2013) on advances regarding [3+2], [4+2] and [2+2] cycloadditions including their miscellaneous version. Advantages of microwave dielectric heating are highlighted by comparison with conventional thermal conditions. In particular, we describe here the microwave effect, reaction media including solvent-free transformations and more ecological processes in the context of green and environmentally benign chemistry.

Cite this article as:

Saber Aziza, Marzag Hamid, Benhida Rachid and Bougrin Khalid, Microwave-assisted Cycloaddition Reactions in Carbo- and Heterocyclic Chemistry, Current Organic Chemistry 2014; 18 (16) . https://dx.doi.org/10.2174/1385272819666140407213427