Abstract
We describe herein a clean and efficient one-pot synthesis of 4H-benzo[b]pyran derivatives using dimedone, active methylene nitriles and aryl aldehyde via Knoevenagel condensation followed by Michael addition in the presence of Mg(NO3)2•6H2O as catalyst and water as a green solvent. The advantages of this method lie in its simplicity, low catalyst loading, cost effectiveness and easy handling. The present method also allows us to synthesize highly functionalized tetrahydrobenzo[b]pyran derivatives from simple and readily available starting materials.
Keywords: Mg(NO3)2•6H2O, multi-component reaction, 4H-benzo[b]pyran, active methylene nitrile, aqua mediated, dimedone.
Graphical Abstract
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