HIV-1 Rev Multimerization: Mechanism and Insights

Title:HIV-1 Rev Multimerization: Mechanism and Insights

Volume: 11 Issue: 8

Author(s): Thomas Vercruysse and Dirk Daelemans

Affiliation:

Keywords: Co-operative interactions, HIV-1, multimerization, protein-protein interactions, protein-RNA interactions, Rev, RNA export, viral replication control.

Abstract: To export intron-containing viral mRNAs that encode the structural components of new viral particles from the nucleus to the cytoplasm, HIV-1 uses the cellular CRM1 export pathway that is exploited by the viral Rev protein. Rev multimerizes on the Rev response element (RRE) present in the intron-containing RNA species to bridge these to the cellular export factor CRM1. As a result, this Rev-RRE complex is exported to the cytoplasm. This review provides a systematic overview of different aspects of the crucial function of Rev multimerization, such as co-operative Rev-Rev and Rev-RNA interactions, the biological function of Rev multimerization, the relevance of Rev multimerization in the absence of RRE and its potential as a therapeutic target.

Cite this article as:

Vercruysse Thomas and Daelemans Dirk, HIV-1 Rev Multimerization: Mechanism and Insights, Current HIV Research 2013; 11 (8) . https://dx.doi.org/10.2174/1570162X12666140307094603