First Girgensohnine Analogs Prepared Through InCl₃-catalyzed Strecker Reaction and their Bioprospection

Title:First Girgensohnine Analogs Prepared Through InCl₃-catalyzed Strecker Reaction and their Bioprospection

Volume: 10 Issue: 6

Author(s): Leonor Y. Vargas Mendez and Vladimir V. Kouznetsov

Affiliation:

Keywords: AChE inhibitory activity, alkaloids, α-Aminonitriles, antioxidant capacity, girgensohnine, Strecker reaction.

Abstract: An efficient preparation of the girgensohnine and its close analogs with α-aminonitrile structure, and their spectral characterization were reported for the first time. The piperidine α-aminonitriles were obtained through 5 mol% InCl₃-catalyzed one-pot Strecker reaction, and tested for antioxidant activity and AChE inhibitory properties. It was found that girgensohnine possesses a moderate AChE inhibitory property while its spiroanalog shows good antioxidant capacity.

Cite this article as:

Mendez Y. Vargas Leonor and Kouznetsov V. Vladimir, First Girgensohnine Analogs Prepared Through InCl₃-catalyzed Strecker Reaction and their Bioprospection, Current Organic Synthesis 2013; 10 (6) . https://dx.doi.org/10.2174/157017941006140206105449